Edwards began writing romances in 1982 and released her 100th novel, Savage Skies, on August 28, 2007. Although her earlier books were classic historical romances, the vast majority of her novels involve Native American tribes. Edwards's grandmother was a full-blooded Cheyenne. Her first 99 books sold a combined 10 million copies as of August 2007, with her more recent novels averaging sales of 250,000–350,000 copies.
Edwards has won the Romantic Times Lifetime Achievement Award and the Romantic Times Reviewer's Choice Award, as well as being named one of Affaire de Coeur's top ten favorite romance writers. Edwards has a reputation for meticulously researching the proper anthropological backgrounds of each tribe she writes about.
Edwards and her husband Charles, a retired high school biology teacher, have been married for over 50 years. They have two sons, Charles and Brian, and three grandchildren. The family lived in St. Louis, Missouri for over thirty years, but now reside in Mattoon, Illinois.